Thursday, June 7, 2012

How plants make cocaine

Wednesday, June 6, 2012

Humans encounter alkaloids every day, they constitute a very large group of natural nitrogen-containing compounds with diverse effects on the human organism. A large variety of plant-produced alkaloids have strong pharmacological effects, and are used as toxins, stimulants, pharmaceuticals or recreational drugs, including caffeine, nicotine, morphine, quinine, strychnine, atropine and cocaine. Atropine, used to dilate the pupils of the eye, and the addictive drug cocaine are both tropane alkaloids which possess two distinctive, inter-connecting five- and seven-membered rings.

Plants commonly produce tropane and other alkaloids for protection against herbivores and other enemies. Species in seven plant families are known to produce tropane alkaloids, including the Brassicaceae (mustard family), Solanaceae (nightshade or potato family) and Erythroxylaceae (coca family). These families are not closely related to each other. For example, it is assumed that the last common ancestor of the Erythroxylaceae and the Solanaceae lived about 120 million years ago. But how similar are the tropane alkaloid biosynthetic pathways in these families? Was there a single original tropane alkaloid pathway which was lost in most other plant families during the course of evolution? Or, did tropane alkaloid biosynthesis arise independently on several different occasions?

Atropine and cocaine: Two tropane alkaloids, two plant species, two different enzymes

John D'Auria, project leader in the Department of Biochemistry at the Max Planck Institute for Chemical Ecology, has been studying the coca plant, from which the drug cocaine is derived. Native tribes in South America have been cultivating coca and chewing its leaves for at least 8000 years for their stimulant and hunger-suppressing properties.

Although the formation of cocaine has not been investigated in the last 40 years, the biosynthesis of the related tropane alkaloid, atropine, from belladonna (Solanaceae) is well-established. In the penultimate step, a ketone function is reduced to an alcohol residue. This key reaction is catalyzed by an enzyme of the short-chain dehydrogenase/reductase (SDR) protein family in belladonna. Among this group of enzymes are also many alcohol-degrading dehydrogenases in animals.

To find the corresponding enzyme in cocaine biosynthesis, Jan Jirschitzka, a PhD student in the group, searched the genome of the coca plant to look for SDR-like proteins. However, all the SDR genes that he cloned and expressed did not show any activity for the key reaction in cocaine formation. So he used a more classical approach ? identifying the cocaine-synthesizing enzyme activity in extracts from coca leaves, purifying the responsible protein, isolating the polypeptide, and ? after partial sequencing ? cloning the corresponding gene.

Cocaine in young leaves, atropine in roots

"We obtained two very interesting results," says Jonathan Gershenzon, director at the institute. "The enzyme reaction analogous to that in atropine synthesis ? the conversion of the keto group into an alcohol residue ? is catalyzed by a completely different enzyme in coca plants as compared to that in the Solanaceae, namely by an aldo-keto reductase (AKR)." The enzyme was named methylecgonone reductase (MecgoR). AKR enzymes are known in plants and also mammals, amphibians, yeast, protozoa, and bacteria. They are involved in the formation of steroid hormones, for example. The second result is that the MecgoR gene, as well as the protein, is highly active in the very young leaves of coca plants, but not in the roots. Atropine, on the other hand, is synthesized exclusively in the roots of belladonna, from where it is transported into the green organs of the plant. Based on these results, the Max Planck researchers conclude that the tropane alkaloid pathways in coca and belladonna evolved completely independently.

Elucidation of the MecgoR-catalyzed step in cocaine biosynthesis represents a major success, but the researchers are now continuing to investigate other important steps in the cocaine pathway. Also of interest is to learn how cocaine is stored in leaf tissue in such high amounts. This alkaloid can account for up to 10% of the dry weight of the immature coca leaf, a phenomenal amount for the accumulation of any one particular alkaloid. [JWK/AO]

###

Jan Jirschitzka, Gregor W. Schmidt, Michael Reichelt, Bernd Schneider, Jonathan Gershenzon, John C. D?Auria: Plant tropane alkaloid biosynthesis evolved independently in the Solanaceae and Erythroxylaceae. Proceedings of the National Academy of Sciences USA, Early Edition, June 4, 2012, DOI: 10.1073/pnas.1200473109

Max Planck Institute for Chemical Ecology: http://www.ice.mpg.de

Thanks to Max Planck Institute for Chemical Ecology for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Wednesday, June 6, 2012

1 space shuttle already at museum, 2 more to go

In this Thursday, July 21, 2011 photo, a worker hangs a sign in a window of the space shuttle Atlantis after it landed at the Kennedy Space Center in Cape Canaveral, Fla. It was on view to employees and the media. The landing of Atlantis brought the space shuttle program to an end. (AP Photo/J Pat Carter)

In this Thursday, July 21, 2011 photo, a worker hangs a sign in a window of the space shuttle Atlantis after it landed at the Kennedy Space Center in Cape Canaveral, Fla. It was on view to employees and the media. The landing of Atlantis brought the space shuttle program to an end. (AP Photo/J Pat Carter)

In this Thursday, April 19, 2012 photo provided by NASA, the space shuttle Discovery is suspended from a sling held by two cranes after a Boeing 747 carrier backed away at Washington Dulles International Airport in Sterling, Va. (AP Photo/NASA, Bill Ingalls)

FILE - In this Wednesday, June 1, 2011 file photo, the space shuttle Endeavour is towed to the Orbiter Processing Facility after its final landing, following a 16 day mission to the International Space Station, at the Kennedy Space Center in Cape Canaveral, Fla. (AP Photo/John Raoux)

The space shuttle Enterprise makes the final leg of its journey to its new Manhattan home on the flight deck of the Intrepid Sea, Air & Space Museum. Wednesday, June 6, 2012, in New York. The U.S. space agency, NASA, ended its shuttle program last year. (AP Photo/Richard Drew)

The space shuttle prototype Enterprise moved to its new home Wednesday, the flight deck of the Intrepid Sea, Air & Space Museum on the Hudson River in New York.

NASA's three real space shuttles ? the ones that rocketed into orbit ? also will spend their retirement in museums.

One is already on display. The other two will follow by year's end.

A quick look at each ship:

Discovery: Flown in April to Smithsonian's Udvar-Hazy Center near Washington Dulles International Airport in Virginia, taking the place of Enterprise. Fleet leader with 39 missions. Oldest survivor of the real shuttles. First flight in 1984, 39th and last in February-March 2011. Spent 365 days in space, traveled 148 million miles.

Endeavour: Still at Kennedy Space Center. Will be flown in September to California Science Center in Los Angeles. Youngest shuttle, built as replacement for the destroyed Challenger. First flight in 1992, 25th and last in May-June 2011. Spent 299 days in space, traveled 123 million miles.

Atlantis: Still at Kennedy Space Center. Will be transported down the road to the Kennedy Space Center Visitor Complex in November. First flight in 1985, 33rd and last in July 2011. Spent 307 days in space, traveled 126 million miles.

Enterprise: Flown in April from Smithsonian to New York. Prototype shuttle used in five approach-and-landing tests at Edwards Air Force Base, Calif., in 1977; dropped off back of modified jumbo jets with two-man astronaut crews and guided to landings. Never flew in space nor was it designed to do so. Used in NASA tests and traveling exhibits, then given to Smithsonian in 1985.

Associated Press

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New testing could help spot genetic disorders

In a development scientists are calling a "tour de force," researchers have reconstructed the genome of a fetus using DNA samples from the parents.

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Because their technique did not require an invasive test to take samples from the fetus itself, it's an important step toward what could become a low-risk way to identify genetic disorders early in development, experts say.

Currently, "when genetic testing is done, it's done for just a few diseases," said lead author Dr. Jay Shendure, an associate professor of genome sciences at the University of Washington.

A test based on the new technique could detect the roughly 3,000 conditions known as Mendelian disorders, each of which are the result of a single mutated gene, Shendure said. Huntington's disease, hemophilia and sickle-cell anemia fall into this category.

While each of these disorders is relatively rare, together they affect about 1 percent of births, Shendure said.

"This is amazing," said Dr. Ada Hamosh, director of the Institute of Genetic Medicine at the Johns Hopkins University School of Medicine, of the findings. "On the other hand, in no way is this ready for prime time," said Hamosh, who was not involved with the research.

Shendure and colleagues put together the fetal genome using a saliva sample from the father, and a sample of blood plasma from the mother. About 13 percent of the DNA found outside of cells in a pregnant woman's body belongs to her fetus.

They sequenced the regions of DNA they were aiming for with 98.2 percent accuracy.

Shendure estimated that reconstructing the fetal genome cost roughly between $20,000 and $50,000.

But with the cost of genome sequencing expected to come down, and as the technique is further refined, Shendure said, the hope is that researchers can develop a clinical test that detects many diseases noninvasively.

It's also hoped that testing could be done earlier in pregnancy than current tests, he said. In the study, the researchers sequenced the fetal genome twice, once in a fetus at 8 weeks into the pregnancy, and another time with a different fetus at 18 weeks. The highly accurate information only came at the later time.

The accuracy is affected variations between pregnancies, Shendure noted. "It's possible it could be done in the first trimester, it just may require more resources to do it."

At present, the only test routinely done that uses maternal blood plasma, as in the study, is for Down syndrome.

But to confirm the results of that blood test, an invasive test called amniocentesis, which requires fetal tissue samples, is used, said Dr. Laird Jackson, a professor of obstetrics and gynecology at the Drexel University School of Medicine.

Hamosh said that while a noninvasive test would be an improvement, at present, a full analysis of a fetus's genome would be overkill, because parents can be tested for specific genes of concern, and a fetus could be tested if the parents' tests reveal a potential problem.

"You don't need whole genome sequence information on a fetus," she said. If a family is known to carry a risky version of a gene, then a test for that gene can be done.

But as the techniques used in the study are improved, she said, they could be helpful in catching cases where new mutations arising in the fetus are the source of genetic diseases, rather than mutations inherited from the parents.

"I think this paper is a tour de force," Hamosh said. "This was unthinkable six months ago. Is it ready for any kind of clinical application? Not at all yet."

While a noninvasive test may be at least several years from the clinic, Jackson said, ultimately they could be a boon for parents, providing more of them with more information about their future children.

With current invasive tests, "if you go to the right person, if you go to a center that has excellent [health professionals], the risk of losing that pregnancy is so small," Jackson said.

But many mothers can?t get to those top-notch facilities, he said.

A noninvasive diagnostic test could increase access, Jackson said. "Now mommy only has to go some place where someone can draw her blood."

More stories from MyHealthNewsDaily

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Construction in Colombia ? Key Trends and Opportunities to 2016 ...

The value of the Colombian construction industry recorded a compound annual growth rate (CAGR) of 11.04% during the review period (2007?2011). This growth was fuelled by the significant levels of foreign investment the country received during the review period in areas such as mining and energy, as security improvements, steady economic growth, a stable political situation and business-friendly policies made the country increasingly attractive to foreign investors. The value of the Colombian construction industry is expected to register a CAGR of 7.33% over the forecast period (2012?2016). The Colombian infrastructure construction market accounted for 52.5% of the total value of the Colombian construction industry in 2011, and the value of the market recorded a strong CAGR of 12.71% during the review period. This growth was primarily attributable to significant infrastructure investments made by the Colombian government, coupled with increased private investment in Colombian infrastructure development.

Scope

  • This report provides a comprehensive analysis of the construction industry in Colombia:
  • Historical (2007-2011) and forecast (2012-2016) valuations of the construction market in Colombia using the construction output and value-add methods
  • Segmentation by sector (commercial, industrial, infrastructure, institutional and residential) and by project type
  • Breakdown of values within each project type, by type of activity (new construction, repair and maintenance, refurbishment and demolition) and by type of cost (materials, equipment and services)
  • Analysis of key construction industry issues, including regulation, cost management, funding and pricing
  • Assessment of the competitive environment using Porter?s Five Forces
  • Detailed profiles of the leading construction companies in Colombia
  • Profiles of the top ten construction mega-projects in Colombia by value

Report Details:

Published:?June 2012
No. of Pages:?236

Price: Single User License: US $1950 ? ? ? ? ? ? ? ? ?Corporate User License: US $5850

Key highlights

  • Residential and infrastructure are the key markets in the Colombian construction industry. With share of 52.5% in 2011, infrastructure was the largest market, followed by the residential market that constituted a share of 34.7% in the same year.
  • According to Colombia?s Ministry of Transportation Investment Plan, COP99.3 trillion (US$56.3 billion) is expected to be invested in transport infrastructure development over the next ten years. Notably, the rapid development of Colombia?s mining industry has necessitated construction of ports and railways for the transportation of mined coal.
  • Driven by continued investments, the value of the Colombian infrastructure construction market is expected to record a CAGR of 7.91% over the forecast period.
  • The Colombian government plans to build one million homes over the next four years at a total cost of approximately COP81.2 trillion (US$43.5 billion), with 70% of these homes expected to provide housing solutions for low-income families. The residential construction market is anticipated to record a CAGR of 6.76% over the forecast period.

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Tuesday, June 5, 2012

Retreating glaciers are a threat to biodiversity

ScienceDaily (June 5, 2012) ? The projected disappearance of small glaciers* worldwide threatens to eliminate the water supply for numerous towns in valleys, such as the Ecuadorian capital Quito, fed by the rivers that flow down from the surrounding mountains. But retreating ice is also a threat to freshwater fauna. According to a study published in Nature Climate Change, the local and regional diversity of mountain aquatic fauna will be reduced considerably if predictions are realised. Until now, the impact of global thawing on biodiversity in watercourses had never been calculated in detail.

Insects, a model group

The research team(1) has focused on the future for populations in streams formed by meltwater in the Alps, Alaska and the equatorial Andes, where the IRD researchers have been working. The IRD team has collected samples from around fifty different sites in the p?ramos. These highly particular herbaceous ecosystems are typical of Andean summits, situated at over 3,500m in altitude between the limits of the forest and the permanent snowline. Ecologists have calculated the population of macroinvertebrates - mainly insect larvae such as Ephemeroptera, Trichoptera and Diptera. These organisms that mostly live at the base of glacial torrents belong to a group that has already been studied extensively, whose environmental needs are relatively well known, and as such can be considered as a model for scientists. For example, following over a year of regular sampling, over 150 species of invertebrates have been identified living in just one p?ramo in the Antisana volcano, the 'water tower? serving Quito.

Extinction between 10 and 40%

In the three regions being studied - temperate, arctic and tropical -, the research team has analysed the reaction of three key elements to the changes in glacial coverage: the local taxonomic diversity (the number of different species present in a stream, for example), or at a regional level (across a hydrographic network, for example), and the variation in this diversity between watercourses. Thanks to this sampling at varying distances from glaciers, the data has revealed that the local diversity increases when moving further downstream. In addition, it seems that the populations in different streams at the same altitude is highly consistent. Within a distance of around one hundred metres, the populations found in two streams that appear the same can be substantially different according to which glacier they drain from. Indeed, the Andean glaciers have diverse actions, melting slower or faster according to their size, which varies greatly, and their exposure to sunlight, for example.

According to these tests, in addition to data from aquatic population studies dating back over 20 years, as soon as the glacial coverage is reduced to the point where it only covers 30 to 50% of the drainage basin, several species begin to disappear. And if the glaciers melted completely, between 11 and 38% of the regional diversity might become extinct, depending on the area being studied, including endemic species.

Fauna unique to these areas

High mountain regions are like isolated islets - migration by new species is restricted and they are favourable to speciation(2). Low temperatures and atmospheric pressure, intense solar rays, irregular rainfall, searing winds, ice... all of these extreme conditions have driven forced the native species to adapt in singular ways, particularly in the tropical Andes. Glacial torrents also impose difficult living conditions on their inhabitants, due to their low mineral content(3) and daily floods(4) that produce major disturbances. A high level of endemism thus characterises the p?ramos, containing species not found anywhere else on Earth, but also inexorably threatened by extinction if glaciers continue to recede.

A loss in services rendered

This study has demonstrated the crucial role played by glaciers in the creation and dynamism of biodiversity, and thus the impact of their reduction for the preservation of this diversity. But this is not the only blow for the planet. The insects play a major role in the functioning of mountain ecosystems, particularly through decomposition of organic matter that enables soil to be formed. They can also be useful downstream, for the 2 million inhabitants of Quito, for example. For these organisms also function as bio-indicators for the quality of the water that supplies the city and can be used as a tool by those who manage this resource. The threat of extinction of several species has led to fears for the loss of these crucial services provided by the ecosystem.

The ecological role played by the majority of invertebrates under threat in glacial rivers is still not well known. The consequences at higher trophic levels, such as for fish, amphibians, birds and mammals, are difficult to predict. But these exceptional ecosystems seem to be condemned to disappear, before they have even had the offer up all of their secrets to researchers.

* see news sheet no.127 - Small glaciers in the tropical Andes: a forewarning of disappearance (http://www.ird.fr/la-mediatheque/fiches-d-actualite-scientifique/127-petits-glaciers-des-andes-tropicales-une-disparition-annoncee)

Notes:

(1) These studies have been led by the IRD and the University of Copenhagen, Denmark, in collaboration with the universities of Birmingham and Leeds in the UK, Alaska in the US and Paris-Sud 11, as well as the Pontificia Universidad Cat?lica del Ecuador in Quito, and the CNRS.

(2) An ongoing process leading to the emergence of new species.

(3)? Environments less rich in minerals are generally unfavourable for aquatic fauna that draw crucial elements for survival from the water, such as chlorides or sodium.

(4) During the day, the glacier melts and increases the flow in streams, whereas the flows diminish at night.

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Story Source:

The above story is reprinted from materials provided by Institut de Recherche pour le D?veloppement (IRD), via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal References:

  1. Dean Jacobsen, Alexander M. Milner, Lee E. Brown, Olivier Dangles. Biodiversity under threat in glacier-fed river?systems. Nature Climate Change, 2012; 2 (5): 361 DOI: 10.1038/nclimate1435
  2. Dean Jacobsen, Olivier Dangles. Environmental harshness and global richness patterns in glacier-fed streams. Global Ecology and Biogeography, 2012; 21 (6): 647 DOI: 10.1111/j.1466-8238.2011.00699.x

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

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Venus? Transits Through History

Three views of the 2004 Venus transit. Credit: NASA

Three views of the 2004 Venus transit. Credit: NASA

In a matter of hours, lucky observers with clear skies will be able to watch Venus pass in front of the Sun. Transits of Venus are rare ? this is the last one until 2117 ? but that?s not the only reason you should find a way to watch it. This astronomical event is historically very significant. Since the 17th century astronomers have used Venus transits to better understand the Universe and our place within in, and the upcoming transit doesn?t break this centuries-old tradition.

The Transit of Venus

Before exploring the role of Venus transits in history, it?s worth taking a couple of steps back. It?s worth looking at the geometry of our Solar System to understand why this event is so rare.

Horrocks observing the 1639 Venus Transit. Published in the US before 1923 and public domain in the US.

Horrocks observing the 1639 Venus Transit. Published in the US before 1923 and public domain in the US.

Venus takes about 225 days to make one full orbit around the Sun while the Earth takes about 365 days. The two planets line up roughly once every year and a half; Venus lies directly between the Earth and the Sun. But we don?t see a transit every time because Venus? orbit is tilted by about three degrees compared to Earth?s. From our perspective, we see Venus passing near the Sun on these occasions but not crossing it. Transits occur when the Earth and Venus line up at the same inclination of their orbits. That?s when we see the planet as a small dot crossing the Sun, and it?s a much rarer occurrence. Venus transits come in pairs eight years apart, but pairs come less than once per century. The repeating pattern between transits is eight years, 105.5 years, eight years, and 120.5 years.

But astronomers didn?t always know the transit schedule. In fact, they didn?t know nearly as much about planetary orbits as we know now. Getting a sense of where astronomy was as a science before transits became a valuable tool for astronomers is also worthwhile before getting into the story of transits in history.

Where We Stood

Illustration of the Venus transit from James Ferguson's 1811 Astronomy, Explained Upon Sir Isaac Newton's Principles. Credit: NASA Goddard Space Flight Center

Illustration of the Venus transit from James Ferguson's 1811 Astronomy, Explained Upon Sir Isaac Newton's Principles. Credit: NASA Goddard Space Flight Center

Until 1543, we were the centre of the Universe. Aristotelean and Ptolemaic models of cosmos had the Moon, Mercury, Venus, the Sun, Mars, Jupiter, and Saturn orbiting around the Earth against the background of fixed stars. But astronomers observed odd behaviour like planets occasionally doubling back on their orbits that couldn?t be explained in this geocentric model. Polish astronomer Nicolaus Copernicus proposed an elegant, and controversial, solution. He decentered the Earth and posited that all planets, including the Earth, orbit the Sun. In this model, the odd planetary motions astronomers saw could be chalked up to their orbiting viewpoint. Copernicus published his model the year of his death, 1543, in his De revolutionibus orbium coelestium (On the Revolutions of the Celestial Spheres). Though he didn?t see it, he changed the cosmic world view to one with a heliocentric system.

George Forbes, "The Transit of Venus", London and New York, 1874. Credit: Adler Planetarium Online

George Forbes, "The Transit of Venus", London and New York, 1874. Credit: Adler Planetarium Online

German astronomer Johannes Kepler built on Copernicus? heliocentric model. Copernicus had retained the ancient idea that planets orbit the sun in perfect circles, but again the observations were inconsistent with the model. Kepler found that the planets actually trace elliptical orbits around the Sun, a theory he proved by using his model to accurately predict the November 7, 1631 transit of Mercury. In 1627, he also predicted the 1631 transit of Venus.

The 1631 Venus transit wasn?t visible in Europe, and Kepler, who died in 1630, failed to this transit?s pair. He predicted a Venus transit in 1761 and a near transit in 1639. He was wrong, and English astronomer Jeremiah Horrocks found the error and used Kepler?s adjusted calculation to predict the 1639 event. At around quarter past three on the afternoon of December 4 that year, he became one of the first men in history to observe a Venus transit. He projected the sun onto a piece of paper through a telescope. His friend William Crabtree also watched the event. Horrocks used his observations to guess at Venus? size and compared data with Crabtree to estimate the distance between the Earth and the Sun.

From the Earth to the Sun

A photograph of the 1882 transit. Credit: The US Naval Oceanography Portal

A photograph of the 1882 transit. Credit: The US Naval Oceanography Portal

The actual distance between the Earth and the Sun eluded astronomers in the 17th century. By the 1660s, the Copernican heliocentric model was widely accepted and the planets? relative orbits were well known. The missing piece was a number. Everything was quantified by the valueless Astronomical Unit (AU) where 1 AU is the average distance from the Sun to the Earth. Venus was known to orbit on average 0.7 AU from the Sun, but that wasn?t the precise value astronomers wanted. If they could determine the value for 1 AU, they could figure out the size of every planet?s orbit and the picture of the solar system, at least as it was understood at the time, would be complete.

Edmund Halley of Halley?s Comet fame was the first astronomer to come up with a way of using the transit of Venus to find the value for 1 AU. If two astronomers observed the transit from two far apart locations on Earth, they could use the difference in transit time and their known distance from each other to calculate the distance between the Earth and Venus. Then, applying Kepler?s third law about the shape of planetary orbits ? the square of the orbital period of a planet is directly proportional to the cube of the semi-major axis of its orbit ? they could determine the value of 1 AU.

French astronomer Joseph-Nicolas Delisle improved on Halley?s method. He stipulated that if the two observers knew their exact positions on Earth, they would only need to record the moment when the edge of Venus lined up with the edge of the Sun. This would be enough to calculate the value of 1 AU.

Measuring the Solar System with Transits

Venus. Credit: NASA

Venus. Credit: NASA

Halley died in 1742, 19 years before he could try his method on the 1761 transit. But a host of astronomers took up the challenge in his stead. European expeditions set out to India, the East Indies, Siberia, Norway, Newfoundland, and Madagascar to get the best and most spaced out views of the event. From the whole worldwide network, more than 120 transit observations were recorded, but most were of poor quality stemming from optical problems and inexperienced observers. For the 1769 transit, more than 150 observations were recorded from Canada, Norway, California, Russia, and famously Tahiti as part of Captain James Cook?s first expedition. But the results were only marginally better.

The state of technology in the 17th century made it impossible to record the exact moments of the start and end of the transit because of the so-called black drop effect. As Venus crossing in front of the Sun, a haze obscured the planet making it impossible for astronomers to make clear observations. But even poor results are results. In 1771, French astronomer J?r?me Lalande combined the observations from the 1761 and 1769 transits and calculated that 1 AU was 95 million miles (153 kilometers) give or take a half million or so miles. It was a start, but it wasn?t the precise value astronomers had hoped for.

Over a century later, a new generation of astronomers sought to use the 1874 and 1882 pair of Venus transits to refine the value of 1 AU. This time around, reigning astronomical superpowers France and England weren?t the only nations mounting expeditions for the event. Austria, Belgium, Brazil, Denmark, Germany, Italy, Mexico, the Netherlands, Portugal, Russia, and the United States all joined in the international effort, though it was far from the organized enterprise we see in international cooperatives today.

A new technology was also on hand for this set of 19th century transits: photography. Most astronomers felt their photographic recording wasn?t good enough to provide accurate measurements. Only the American astronomers felt the 200 photographs they took during the 1874 transit were promising enough to try again in 1882.

The 1882 transit was visible in the United States, and the U.S. Naval Observatory produced nearly 1,400 photographs. Though a striking record, these and other images gathered from other sites around the world did little to perfect the standing value of 1 AU. American astronomer William Harkness studied the 1874 and 1882 photographs and came up with a value of 92,797,000 miles (149,342,295) give or take 59,700 miles for 1 AU. This was better, but it still wasn?t accurate enough. The black drop effect remained; perfect Earth-based observations can never be free from the distorting effects of the atmosphere.

New Technologies, New Goals

Venus begin its transit as seen by NASA's TRACE satellite on June 8, 2004. Credit: NASA/TRACE

Venus begin its transit as seen by NASA's TRACE satellite on June 8, 2004. Credit: NASA/TRACE

Space age technology made short work of the quest to find the value of 1 AU. Radio telemetry from space probes and radar measurements have yielded the value of 92,955,807.273 miles (149,597,870.700 kilometres), give or take about 100 feet. But just because this one big question has been answered doesn?t mean the 2004 and 2012 transits have to break the tradition of astronomers using the event to further our understanding of the Universe around us. This generation just has a very different goal in mind. Instead of measuring our Solar System, this pair of transits is helping astronomers measure the atmospheres of exoplanets.

2004 was the first transit since quantitative astronomical spectroscopy was invented, and astronomers took the opportunity to make detailed spectroscopic measurements of Venus? upper atmosphere. Spectroscopy, which came onto the astronomical scene in the first half of the 20th century, allows astronomers to determine the chemical composition of a planet?s atmosphere. As sunlight passed through Venus? atmosphere, the gases absorbed light at certain known wavelengths. The light that reached Earth had an absorption spectrum that astronomers read to find exactly what makes up the planet?s atmosphere.

Learning more about Venus wasn?t the only reason to decipher its atmosphere in 2004. Taking spectroscopic measurements was a practice run for applying the same method to determining the atmospheric composition of exoplanets ? planets that orbit stars other than the Sun. Astronomers are using this 2012 transit to test another method of studying exoplanets.

Hubble will use its advanced Camera for Surveys, Wide Field Camera 3, and Space Telescope Imaging Spectrograph to view the transit in a range of wavelengths and perform spectroscopic analysis. But because its cameras are too sensitive to point directly at the Sun, Hubble will measure the light passing through Venus? atmosphere as it reflects off the Moon. If Hubble can get an accurate reading of Venus this way, it will be another tool in astronomers? arsenal for determining the atmospheric composition of exoplanets. If there?s an Earth out there, this could be the way to find it.

Over the course of astronomy?s history, Venus transits have shaped and given size to our Solar System. Now, transits are helping us understand our place in the Universe relative not only to other planets and stars but to other possible worlds and life forms. As you watch a small dot cross in front of a circle later, try to keep in mind the significance of and rich history behind this seemingly tiny event.

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Preferred Stock- Debt and Equity | WordNice free nice article ...

Preferred stock performs some degree of ownership in a company but naturally doesn?t come with the voting rights in comparison with common stock. Preferred stocks are an alternative option for investors, which are designed to have a stability, however not guaranteed, income and priority like in order of debt. At the same time, it?s also holding the flexibility offered by equity financing. Investors of preferred stock are always guaranteed with a fixed premium. Preferred stock is better than common stock, as it has variable dividends which is affected by the market and never guaranteed. Because of this quality some people consider preferred share to be more like debt than equity.

Previously in England and then in United States, Preferred stock was used by companies as in building railroads and canals. These companies feel the necessity of more capital possibly made as or it may be brought up as ordinary equity, but their borrowing capability was limited due to the trend of keeping a piece of guarantee of the day in which each loan required. (Separating a railroad line into segments would yield nothing of value.) As a result, the concept of preferred stock was developed, which keep some but not all the rights of debt.

In general business organizations, Preferred stock is taxed in the same way as common stock that receives the double tax collection of dividends. Rather than individuals, corporations receive better after tax-returns from preferred stock, thus corporations are allowed to cut back from their income mostly from the dividends received. Likewise preferred interests in partnerships and LLC?s frequently go through an amount of income based on the preferred return.

Debt and equity are the two classic source of capital for a business. But these are not the only forms that an investment in a company may take. Especially, preferred stock shares with debt the concept of a predictable return paid annually, as well as a right to repayment before of the common equity. Generally, the par value of a preferred stock is generally the amount of its liquidation preference, and the annual dividend is generally declared as a percentage of that figure. In spite of all preferred stockholders cannot carry out actual payment of their return as in first concern of paying back they stand lower than creditors.

In transaction form preferred equity can also be combined with different structure/pattern of investments. From several tools, preferred equity is one of the tools that is used to put together the collection/quantity of rights and returns that gives up a right transaction acceptable to both sides.

Further, the dividends paid from investing in preferred stocks are of a different type and generally considered as a greater investment than that of common stock. Before investing money in preferred stock, you?ll have to know when to except the dividends which are paid often. In matter for common stock, these stocks are decided by company?s board of directors that whether to pay or not, a dividend on a stock. Because of this element, these stocks generally don?t fluctuate as often as a company?s common stock, and sometimes it is also known as a fixed income security. Another fact of this fixed income is that, dividends are generally ensured meaning that if the company misses a payment, it will be required to pay it before any future dividends are paid on any stock.

preferred stock dividends | preferred stock quotes | Canadian preferred Stocks

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