Tuesday, April 30, 2013

EPA methane report further divides fracking camps

PITTSBURGH (AP) -- The Environmental Protection Agency has dramatically lowered its estimate of how much of a potent heat-trapping gas leaks during natural gas production, in a shift with major implications for a debate that has divided environmentalists: Does the recent boom in fracking help or hurt the fight against climate change?

Oil and gas drilling companies had pushed for the change, but there have been differing scientific estimates of the amount of methane that leaks from wells, pipelines and other facilities during production and delivery. Methane is the main component of natural gas.

The new EPA data is "kind of an earthquake" in the debate over drilling, said Michael Shellenberger, the president of the Breakthrough Institute, an environmental group based in Oakland, Calif. "This is great news for anybody concerned about the climate and strong proof that existing technologies can be deployed to reduce methane leaks."

The scope of the EPA's revision was vast. In a mid-April report on greenhouse emissions, the agency now says that tighter pollution controls instituted by the industry resulted in an average annual decrease of 41.6 million metric tons of methane emissions from 1990 through 2010, or more than 850 million metric tons overall. That's about a 20 percent reduction from previous estimates. The agency converts the methane emissions into their equivalent in carbon dioxide, following standard scientific practice.

The EPA revisions came even though natural gas production has grown by nearly 40 percent since 1990. The industry has boomed in recent years, thanks to a stunning expansion of drilling in previously untapped areas because of the use of hydraulic fracturing, or fracking, which injects sand, water and chemicals to break apart rock and free the gas inside.

Experts on both sides of the debate say the leaks can be controlled by fixes such as better gaskets, maintenance and monitoring. Such fixes are also thought to be cost-effective, since the industry ends up with more product to sell.

"That is money going up into the air," said Roger Pielke Jr., a professor of environmental studies at the University of Colorado, adding he isn't surprised the EPA's new data show more widespread use of pollution control equipment. Pielke noted that the success of the pollution controls also means that the industry "probably can go further" in reducing leaks.

Representatives of the oil and gas industry said the EPA revisions show emissions from the fracking boom can be managed.

"The methane 'leak' claim just got a lot more difficult for opponents" of natural gas, noted Steve Everley, with Energy In Depth, an industry-funded group.

In a separate blog post, Everley predicted future reductions, too.

"As technologies continue to improve, it's hard to imagine those methane numbers going anywhere but down as we eagerly await the next installment of this EPA report," Everley wrote.

One leading environmentalist argued the EPA revisions don't change the bigger picture.

"We need a dramatic shift off carbon-based fuel: coal, oil and also gas," Bill McKibbern, the founder of 350.org, wrote in an email to The Associated Press. "Natural gas provides at best a kind of fad diet, where a dangerously overweight patient loses a few pounds and then their weight stabilizes; instead, we need at this point a crash diet, difficult to do" but needed to limit the damage from climate change.

The EPA said it made the changes based on expert reviews and new data from several sources, including a report funded by the oil and gas industry. But the estimates aren't based on independent field tests of actual emissions, and some scientists said that's a problem.

Robert Howarth, a Cornell University professor of ecology who led a 2011 methane leak study that is widely cited by critics of fracking, wrote in an email that "time will tell where the truth lies in all this, but I think EPA is wrong."

Howarth said other federal climate scientists from the National Oceanic and Atmospheric Administration have published recent studies documenting massive methane leaks from natural gas operations in Colorado and other Western states.

Howarth wrote that the EPA seems "to be ignoring the published NOAA data in their latest efforts, and the bias on industry only pushing estimates downward ? never up ? is quite real. EPA badly needs a counter-acting force, such as outside independent review of their process."

The issue of methane leaks has caused a major split between environmental groups.

Since power plants that burn natural gas emit about half the amount of the greenhouse gases as coal-fired power, some say that the gas drilling boom has helped the U.S. become the only major industrialized country to significantly reduce greenhouse emissions. But others believe the methane leaks negate any benefits over coal, since methane is a highly potent greenhouse gas.

The new EPA figures still show natural gas operations as the leading source of methane emissions in the U.S., at about 145 million metric tons in 2011. The next biggest source was enteric fermentation, scientific jargon for belches from cows and other animals, at 137 million metric tons. Landfills were the third-biggest source, at 103 million metric tons.

But the EPA estimates that all the sources of methane combined still account for only 9 percent of greenhouse gases, even taking into account methane's more potent heat-trapping.

The EPA said it is still seeking more data and feedback on the issue of methane leaks, so the report may change again in the future.

The EPA revisions have international implications, too. The agency says the new report, Inventory of U.S. Greenhouse Gas Emissions and Sinks, was submitted to the U.N. Framework Convention on Climate Change by an April 15 deadline.

Source: http://news.yahoo.com/epa-methane-report-further-divides-161201451.html

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Negotiation Expert To Present Public Lecture | Bernews.com

Mario MoussaThe Penn & Wharton Bermuda Alumni Association presents ?Negotiation: How to Get What You Want? with Mario Moussa, MBA, PhD on Wednesday, May 8 from 6pm onward at Fairmont Hamilton Princess ? Harbourview Ballroom.

Admission is free, please register here.

We are pleased to share with Bermuda insights from one of the world?s leading experts in negotiations, business strategy, and collaboration. Everyone is welcome to join Dr. Moussa?s presentation to build skills at using negotiations to create win-wins and get what you want.

Dr. Mario Moussa is a Senior Fellow at Wharton Executive Education, University of Pennsylvania. He teaches negotiation, influence, strategy, change, and corporate culture and is co-director of the Wharton School?s Strategic Persuasion Workshop: The Art and Science of Selling Ideas. A specialist in large-scale organizational change initiatives, he has consulted to many of the world?s leading corporations, universities, and foundations. He is co-author of The Art of Woo: Using Strategic Persuasion to Sell Your Ideas.

The University of Pennsylvania is one of the oldest universities in America and, as a member of the Ivy League, one of the most prestigious institutions of higher learning in the world. Approximately 35 Penn alumni currently live in Bermuda. www.upenn.edu

Founded in 1881 as the first collegiate business school, the Wharton School of the University of Pennsylvania is recognized globally for intellectual leadership and ongoing innovation across every major discipline of business education, including undergraduate, MBA, executive MBA, and doctoral programs. www.wharton.upenn.edu

For more information please contact PennBermuda@gmail.com

Read More About: Bermuda business

Category: All, Business

Source: http://bernews.com/2013/04/negotiation-expert-to-present-public-lecture/

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Monday, April 29, 2013

World leaders love Twitter

Bill Clinton gets a Twitter lesson from Stephen Colbert. (AP/ABC OTUS News)

It?s not just celebrities who love Twitter: South American leaders, it turns out, heart to tweet. Some may even have gone overboard and may have over shared.

A Reuters story reports that when some 1 million protesters hit the streets to criticize the government of Argentina President Cristina Fernandez, she responded by posting 61 tweets over a nine-hour period.

According to the account, the posts from Fernandez ran the gamut from declaring herself ?stubborn,? to defending the benefits of a state-run literacy program, to admiring a fresco in her ?gorgeous? palace.

And in Venezuela, the candidates vying to succeed the late Hugo Chavez had a war of words on Twitter. The eventual winner of the election, Nicolas Maduro, who had been handpicked by Chavez, tweeted that his opposition was ?fascist.? The losing candidate, Henrique Capriles, posted that Maduro was ?an illegitimate president.?

Chavez, who had had his own TV show, had also taken to tweeting. He had 4 million followers when he died.

Being out of office hasn?t quieted the former president of Colombia, ?lvaro Uribe, who has ruffled feathers for apparently posting multiple tweets a day criticizing the current leader.

Over in France, public figures are only too aware of the impact a tweet can have. Valerie Trierweiler, the companion to the president of France, Francois Hollande, got in hot water for her impolitic post supporting the opponent of Hollande?s ex, who was running in a local election.

Maybe this explains former President Bill Clinton?s reluctance to try out the social medium. He only just joined with the encouragement of satiric news host Stephen Colbert, who first started Clinton with the Twitter handle @PrezBillyJeff.

Clinton officially introduced the more respectable @billclinton. Launched last week, the former president already has more than 500,000 followers.

Barack Obama, who famously would not give up his Blackberry when he got to the White House, rarely is the one tweeting from his account @BarackObama. If he does, the posts are signed ?bo.?

There is one leader who's definitely not a Twitter fan. According to Reuters, Brazil's president, Dilma Rousseff, stopped tweeting after she was elected in 2010. An aide told Retuers, "She thinks it's a total waste of time."

Source: http://news.yahoo.com/blogs/lookout/world-leaders-love-twitter-211835156.html

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Friday, April 26, 2013

New App Reveals Painting's Past With a Swipe

A new app for iPhones and iPads lets art viewers see the path a painting took from sketches to completion, from any angle.

Repentir, a free app developed by researchers in the United Kingdom's Newcastle University and Northumbria University, works so far with only one painting. But the developers say that the technology could soon be applied to many new paintings, and maybe even old ones.

"What you could do is take the actual imagery art historians have been making of old paintings and actually use the app as a way to reveal them," said Jonathan Hook,? a professor at Newcastle University who studies human-computer interactions. At present, the app can reveal the history of "Transamerica," a new painting by artist Nathan Walsh. [Top 10 Science Apps for Your Phone]

Both the app and the painting are being formally revealed in Paris today (April 26) at the 2013 Association for Computing Machinery Conference on Human Factors in Computing. Walsh is a realist painter, which often makes art viewers believe he's "cheated" by altering photographs or otherwise not really creating his work by hand, Hook told LiveScience.

"What's really cool about the app is it allows people not just to believe that what Nathan does is real, but to get a handle on the process," Hook said.

"Transamerica" is a street scene as seen reflected in a San Francisco Chinatown gift shop. As he painted, Walsh took a photograph every day of the unfinished canvas, starting from pencil sketches and ending in oil paint. Hook and his colleagues then compiled these photographs into layers. Repentir app users can scroll through the layers using a scroll bar, or they can rub top layers away on-screen with a fingertip, revealing the earlier work underneath.

Viewers can snap a picture of the artwork from any angle as they view it in person, and the program will recognize the picture and adjust the layers accordingly. This means that you can even get up close and photograph just a tiny portion of the picture and the app will still recognize it, Hook said.

"Rather than some alternative approaches like looking for a square shape or a QR code, this actually uses features within the image to match where the painting is," he said.

Repentir currently needs "Transamerica" to work, but any artist with digital photography equipment could join the project, Hook said. "Transamerica" will remain on display in Paris until May 2 and then is set to go to the Bernarducci Meisel Gallery in New York, where Hook and his colleagues plan to study whether the app changes the way art lovers approach the painting.

"The next step is to actually evaluate whether Repentir affects the way that gallery patrons experience Nathan's work," Hook said.

Follow Stephanie Pappas on Twitter?and Google+. Follow us @livescience, Facebook?& Google+. Original article on LiveScience.com.

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/app-reveals-paintings-past-swipe-230221029.html

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Study: New bird flu jumped directly from chickens

In this April 3, 2013 photo, chickens are seen at a chicken farm on the outskirts of Shanghai, China. After a new and lethal strain of bird flu emerged in Shanghai two weeks ago, the government of China's bustling financial capital responded with live updates on a Twitter-like microblog. It's a starkly different approach than a decade ago, when Chinese officials silenced reporting as a deadly pneumonia later known as SARS killed dozens in the south. (AP Photo/Gillian Wong)

In this April 3, 2013 photo, chickens are seen at a chicken farm on the outskirts of Shanghai, China. After a new and lethal strain of bird flu emerged in Shanghai two weeks ago, the government of China's bustling financial capital responded with live updates on a Twitter-like microblog. It's a starkly different approach than a decade ago, when Chinese officials silenced reporting as a deadly pneumonia later known as SARS killed dozens in the south. (AP Photo/Gillian Wong)

LONDON (AP) ? Chinese scientists have for the first time found strong evidence of how humans became infected with a new strain of bird flu: from chickens at a live market.

Chinese scientists compared swabs from birds at markets in eastern China to virus samples from four patients who caught the new H7N9 virus. The scientists found the virus from one patient was nearly identical to one found in a chicken. The research was published online Thursday in the journal Lancet.

Finding definitive proof of how patients were infected is very difficult and experts have so far struggled to find much virus in birds. Despite taking nearly 48,000 samples from animals in live markets, Chinese officials found only 39 positive tests for H7N9. Experts had suspected birds in live markets to be the source of infection but weren't sure if other animals or wild birds might also be responsible.

Health officials have so far refrained from recommending any wide-scale slaughter of poultry to contain the disease, one of the main tools used previously to combat another bird flu strain, H5N1. Unlike that strain, H7N9 doesn't appear to sicken chickens, giving experts fewer signs as to where it might be spreading.

Chinese authorities have shut down live poultry markets in many affected regions, which seems to have slowed down the virus. Still, Taiwan reported its first case earlier this week.

So far, H7N9 has infected more than 100 people in China and killed more than 20.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2013-04-25-EU-MED-China-Bird-Flu/id-79c2a8d00d5b45bcb6ea8522cba8351b

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Thursday, April 25, 2013

Realogy Announces Pricing of Its Offering of ... - Franchising.com

MADISON, NJ--(Marketwired - Apr 23, 2013) - Realogy Holdings Corp. (NYSE: RLGY) (the "Company") announced today that its indirect, wholly-owned subsidiary, Realogy Group LLC ("Realogy Group"), together with a co-issuer, priced $500 million aggregate principal amount of 3.375% senior notes due 2016 (the "Notes") in connection with their previously announced private offering exempt from the registration requirements of the Securities Act of 1933, as amended (the "Securities Act"). The size of the offering has been upsized from $450 million to $500 million. The closing of the offering is expected to occur on April 26, 2013, subject to customary closing conditions.

The Notes will be guaranteed on an unsecured senior basis by each of Realogy Group's domestic subsidiaries (other than the co-issuer of the Notes) that is a guarantor under its senior secured credit facility and certain of its outstanding securities. The Notes will also be guaranteed by the Company on an unsecured senior subordinated basis. The Notes will be effectively subordinated to all of Realogy Group's existing and future senior secured debt, including its senior secured credit facility and its outstanding senior secured notes, to the extent of the value of the assets securing such debt.

The Company intends to use the net proceeds from the offering of the Notes of approximately $494.5 million, along with borrowings under its revolving credit facility, to redeem all of the $492 million aggregate outstanding principal amount of 11.50% Senior Notes due 2017 at a redemption premium of 105.75%, plus accrued and unpaid interest to the redemption date. The proposed offering of the Notes is subject to market and other conditions, and may not occur as described or at all.

The Notes and the related guarantees will not be registered under the Securities Act or any state securities law and may not be offered or sold in the United States absent registration or an applicable exemption from registration under the Securities Act and applicable state securities laws. The Notes and the related guarantees will be offered in the United States only to qualified institutional buyers under Rule 144A of the Securities Act and outside the United States under Regulation S of the Securities Act.

This press release shall not constitute an offer to sell, or the solicitation of an offer buy, any securities, nor shall there be any sales of securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. This press release is being issued pursuant to and in accordance with Rule 135(c) under the Securities Act.

About Realogy

Realogy Holdings Corp. (NYSE: RLGY) is a global leader in residential real estate franchising with company-owned residential real estate brokerage operations doing business under its franchise systems as well as relocation and title and settlement services. Realogy's brands and business units include Better Homes and Gardens? Real Estate, CENTURY 21?, Coldwell Banker?, Coldwell Banker Commercial?, The Corcoran Group?, ERA?, Sotheby's International Realty?, NRT LLC, Cartus and Title Resource Group. Collectively, Realogy's franchise system members operate approximately 13,600 offices with 238,900 independent sales associates doing business in 102 countries around the world. Realogy is headquartered in Madison, N.J.

Forward Looking Statements

Certain statements in this press release constitute "forward-looking statements" relating to the offering of the Notes and the anticipated use of net proceeds therefrom. Statements preceded by, followed by or that otherwise include the words "believes", "expects", "anticipates", "intends", "projects", "estimates" and "plans" and similar expressions or future or conditional verbs such as "will", "should", "would", "may" and "could" are generally forward-looking in nature and not historical facts. Any statements that refer to expectations or other characterizations of future events, circumstances or results are forward-looking statements. These statements are subject to significant risks and uncertainties, including, without limitation, risks and uncertainties related to economic, market or business conditions and satisfaction of customary closing conditions related to the private offering. No assurance can be given that the offering of Notes discussed above will be consummated on the terms described or at all. Except for our ongoing obligations to disclose material information under the federal securities laws, we undertake no obligation to release publicly any revisions to any forward-looking statements, to report events or to report the occurrence of unanticipated events unless we are required to do so by law.

Contacts:

Investor Relations

Alicia Swift
(973) 407-4669
alicia.swift@realogy.com

Jennifer Pepper
(973) 407-7487
jennifer.pepper@realogy.com

Media?

Mark Panus
(973) 407-7215
mark.panus@realogy.com

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Source: http://www.franchising.com/news/20130424_realogy_announces_pricing_of_its_offering_of_senio.html

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China Visit Sparks Dynamic Engagements, Dempsey Says | Albany ...

U.S. Army Gen. Martin E. Dempsey, left, chairman of the Joint Chiefs of Staff, meets with Chinese President Xi Jinping in Beijing, April 23, 2013. DOD photo by D. Myles Cullen

U.S. Army Gen. Martin E. Dempsey, left, chairman of the Joint Chiefs of Staff, meets with Chinese President Xi Jinping in Beijing, April 23, 2013. DOD photo by D. Myles Cullen


Published: April 24, 2013

By Albany Tribune

By Karen Parrish

With his visit to China nearly complete, Army Gen. Martin E. Dempsey said today he has been afforded good access to senior Chinese leaders, junior leaders and future leaders.

Dempsey, the chairman of the Joint Chiefs of Staff, said during a media roundtable that one thread common to the meetings he?s attended here is that with power comes responsibility ? local, regional and, increasingly, global.

Dempsey said his discussions in China, which is widely considered the world?s greatest rising power, have ranged from regional concerns such as territorial disputes to the potentially global issue of North Korea?s nuclear ambitions. Other major topics in his talks here this week, he said, included growing risk in the cyber domain and the U.S. rebalance to the Asia-Pacific region.

Earlier this week, Dempsey met separately with Chinese President Xi Jinping and State Councilor Yang Jiechi. He also met individually and in some group meetings with senior Chinese army officers, including Gen. Chang Wanguan, minister of national defense; Gen. Fan Changlong, vice chairman of the Central Military Commission; and his host for this visit, Gen. Fang Fenghui, chief of the general staff.

Addressing reporters? questions on North Korea today, Dempsey said the ballistic missile and nuclear tests Pyongyang has conducted show that nation is ?on a path that will certainly increase risk in the region, and ultimately could present risk globally.?

The United States has responded to North Korean provocations in the past, he noted, by denouncing North Korea?s path toward nuclear weapons and its failure to live up to agreements and U.N. Security Council resolutions against such development. The U.S. military posture toward a nuclear-armed North Korea is one of deterrence and preparedness, the chairman said.

?If they were to launch, we do have the capability to defend ourselves, our people, our facilities,? Dempsey added.

China, North Korea?s primary ally along with Russia, has been very clear that among its national interests is a non-nuclearized Korean Peninsula, Dempsey said. He added that he will leave China believing that its leaders are ?as concerned as we are? about the issue.

Dempsey said his meetings here did not touch on specific measures the Chinese might take in response to further North Korean actions.

?We think there?s still time for North Korea?s leaders to back away from further provocations, and we certainly hope they take the opportunity to do so,? he added.

To questions on cyber concerns involving China, Dempsey said he has the advantage of being able to build on decisions that already have been taken. He noted that during Secretary of State John F. Kerry?s visit here earlier this month, the Chinese agreed to form a cyber working group.

?I reinforced my belief that that was timely and appropriate,? the chairman said. ?We had a very useful discussion about how the challenges in cyber are migrating from theft to disruption, and left unaddressed, are likely to lead to destruction.?

The nations that have the strongest economies and rely most on technology are most vulnerable to cyber activity, Dempsey said. In discussions with Chinese leaders, he said, ?I encouraged them to put their best and brightest minds to seek a level of collaboration and transparency with us, because it will affect both of our futures.?

The chairman said he supports developing a code of conduct for cyber activity, likening the concept to Albert Einstein?s assertion that ?if I had 60 minutes to save the world, I should spend 55 minutes understanding the problem and only five minutes solving it.?

?I think we?re in that ?55 minutes,?? Dempsey said. ?I think we?re in that period of gaining a common understanding. ? Cyber continues to evolve, whether we would like it to or not.?

State, nonstate and individual actors all operate in the cyber domain, he said, and while cyber originated as an open-architecture system designed to allow information to move freely, ?there has to be some code of conduct established.?

The chairman also responded to reporters? questions about the territorial dispute between China and Japan over a group of uninhabited islands in the East China Sea, adjacent to possible undersea oil reserves. Japan refers to them as the Senkaku Islands, while in China they are known as the Diaoyu Islands.

Dempsey noted the United States doesn?t take sides in such disputes and urges peaceful resolution to all such issues.
In discussions, both he and the Chinese were ?very candid? about their respective positions on the islands, he said.

?In the case of Japan, in particular, I was careful to remind them that we do have certain treaty obligations with Japan that we would honor,? the chairman said. ?And therefore, it was in everyone?s best interest that this be resolved peacefully and without military coercion.?

The chairman said many of the senior and mid-level Chinese military leaders he spoke with here sought clarity about the U.S. rebalance to the Asia-Pacific region.

?I think I was successful in describing it as a long-term process,? he said. ?We?ve never suggested this would be something that would manifest itself overnight. But also, it was a strategic imperative for us to rebalance, over time, to the Pacific.?

Economic, security, and demographic trends all lead to the Asia-Pacific region, he said.

?Furthermore, I tell them this wasn?t about them, meaning China. Of course they?re a factor, ? but this wasn?t a strategy that was aimed at them in any way,? Dempsey said.

The chairman added that military considerations are only part of the broader U.S. regional strategy. ?I pointed out to them that among the first visitors who came here after our ? rebalancing initiative was announced was Jack Lew, the secretary of the treasury,? he said.

Dempsey noted that President Barack Obama and Chinese President Xi Jinping have discussed forging a new relationship between the two countries. ?That new relationship will, of course, be established in the context of our other and enduring relationships in the region,? he said.

In every case, Dempsey said, discussion about the rebalance was dynamic.

?I like to believe that my trip here has contributed to a greater understanding of what we?re doing and why,? he said. ?But it?s something that we?re going to have to continue to work over time.?

Today, the chairman visited China?s National Defense University, the 4th Aviation Regiment and the Army Aviation Academy.

The cadets Dempsey spoke with are training to become either maintainers or pilots of aircraft, he noted. In discussion with the Chinese cadets, Dempsey said, ?they probably asked me a dozen or more questions. One of the questions was about an issue of geostrategic importance, and 11 of them were about leadership.?

?It was fascinating, actually,? he added. ?I found them to be genuinely interested in how I described myself as a leader, what were the attributes I thought were important, ? [and] the difference between junior-level leadership and senior-level leadership.?

The chairman said his answer to the cadets was fundamentally the same thing he would tell a junior military leader in the U.S. forces.

?That is, that what we expect our junior leaders to do is to become competent in their chosen fields, so if you?re an aviator, you should aspire to be the best aviator that you can be,? Dempsey said. ?And then, spend as much time thinking about how to be a man or woman of character, because leadership is the combination of competence and character.?

Source: American Forces Press Service

Source: http://www.albanytribune.com/24042013-china-visit-sparks-dynamic-engagements-dempsey-says/

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Just Mobile Gum Max Duo review

A new entrant into the crowded field of portable power supplies has recently arrived from a trusted mobile vendor – Just Mobile. ?It?sports some unique features without missing any of the standard items. The Gum Max Duo (GMD) is Just Mobile’s ?top-of-the-line USB charger, and it packs quite a wallop: 11.2 Amp/hours of power! Let’s [...]

Source: http://the-gadgeteer.com/2013/04/25/just-mobile-gum-max-duo-review/

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Wednesday, April 24, 2013

'Unjustly enriched': Government sues Lance Armstrong

AUSTIN, Texas (AP) ? The federal government is going after Lance Armstrong's money. As much as it can get.

The Justice Department unveiled its formal complaint against Armstrong on Tuesday, saying the cyclist violated his contract with the U.S. Postal Service and was "unjustly enriched" while cheating to win the Tour de France.

The government had previously announced it would join a whistle-blower lawsuit brought by former Armstrong teammate Floyd Landis under the federal False Claims Act. Tuesday was the deadline to file its formal complaint.

The Postal Service paid about $40 million to be the title sponsor of Armstrong's teams for six of his seven Tour de France victories. The filing in U.S. district court in Washington, D.C., says the USPS paid Armstrong $17 million from 1998-2004.

The lawsuit also names former team Armstrong team director Johan Bruyneel and team management company Tailwind Sports as defendants.

"Defendants were unjustly enriched to the extent of the payments and other benefits they received from the USPS, either directly or indirectly," the complaint said.

The financial costs for Armstrong and Bruyneel could be high. The government said it would seek triple damages assessed by the jury. Armstrong has been dropped by his personal sponsors and left the cancer-fighting foundation he started in 1997.

Armstrong had previously tried to negotiate a settlement, but those talks fell through before the government announced it would join the Landis lawsuit. Settlement talks could resume as the case proceeds to trial.

Armstrong, who in January admitted using performance-enhancing drugs after years of denials, has argued that the Postal Service's endorsement of his team earned the government agency far more than it paid him.

Armstrong attorney Elliot Peters called the government's complaint "opportunistic" and "insincere."

"The U.S. Postal Service benefited tremendously from its sponsorship of the cycling team. Its own studies repeatedly and conclusively prove this," Peters said. "The USPS was never the victim of fraud. Lance Armstrong rode his heart out for the USPS team, and gave the brand tremendous exposure during the sponsorship years."

The government must prove not only that the Postal Service was defrauded, but that it was damaged somehow.

Previous studies done for the Postal Service concluded the agency reaped at least $139 million in worldwide brand exposure in four years ? $35 million to $40 million for sponsoring the Armstrong team in 2001; $38 million to $42 million in 2002; $31 million in 2003; and $34.6 million in 2004.

Landis attorney Paul Scott dismissed the idea that money gained by the Postal Service should negate the claims of fraud. Scott the Postal Service is tainted by the drug scandal.

"Even if the USPS received some ephemeral media exposure in connection with Mr. Armstrong's false victories, any illusory benefit from those times will be swamped over time immemorial by the USPS forever being tied to the largest doping scandal in the history of sports," Scott said.

The formal complaint against Armstrong appears to rely heavily on evidence and statements supplied by Landis and gathered by the U.S. Anti-Doping Agency for its 2012 investigation that exposed a doping program on the USPS team. Armstrong has been banned from sports for life and stripped of his seven Tour de France victories.

As Armstrong's teammate, Landis participated in the doping program. He was later stripped of his 2006 Tour de France title won with another team because of his own doping violations.

Bruyneel, who lives in London, also has been charged by USADA with doping violations but is fighting that case in arbitration.

The government notes the contract with the Postal Service required riders to follow the rules of cycling, which included bans on performance-enhancing drugs and methods. Armstrong now admits using steroids, blood boosters and other illegal performance-enhancing drugs and measures to win.

By breaking the rules and covering it up, Armstrong and Bruyneel committed fraud against the U.S. government, the complaint said.

The complaint said that for years, team officials assured the Postal Service that the team wasn't doping.

Armstrong had been the target of a federal criminal grand jury, but that case was closed without charges in February 2012. Armstrong has previously tried to settle the Landis whistleblower lawsuit, but those talks broke down before the government announced its intention to join the case.

Armstrong also is fighting a lawsuit from Dallas-based promotions company SCA to recover about $12 million it paid him in bonuses, and a lawsuit from the London-based Sunday Times, which wants to get back $500,000 it paid him to settle a libel case.

Source: http://news.yahoo.com/justice-says-armstrong-unjustly-enriched-223928621--spt.html

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Mellowest State Has Obama Connection

Apr 24, 2013 3:54pm

If your nerves are a bit frazzled chances are you live in West Virginia. According to the new Gallup-Healthways Well-Being Index released earlier today, residents of this state are the most stressed out in the nation.

Gallup has been tracking the daily stress levels of Americans since 2008. To find out how much the average citizen feels emotional and psychological stress and enjoys life on a daily basis, they polled more than 350,000 people by phone ? despite the fact that numerous studies show increased phone usage can increase anxiety.

Besides West Virginians, more people who live in Rhode Island, Kentucky, Utah and Massachusetts reported a case of frayed nerves the previous day. In all those states over 40 percent of those surveyed admitted they felt some level of stress the day before being interviewed.

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West Virginia is ranked the most stressed state in the nation. Photo credit: Getty Images.

And more people from Rhode Island, Kentucky, New Jersey, New York, and West Virginia seem to be having a miserable time. Nearly 20 percent of people in those states told interviewers they did not enjoy themselves the day before.

Hawaiians, on the other hand, are mellow compared with those who live in the lower 48. For the second year in a row, they seemed to be the most immune to emotional stress and more likely to feel enjoyment. A mere 32 percent of Hawaiians reported feeling stressed out and nearly 90 percent said they were enjoying life. (President Obama was born in Honolulu, Hawaii.)

Other states with the fewest anxious residents included Louisiana, Iowa, Mississippi and Wyoming. After Hawaii, the states with the highest reported enjoyment levels were Wyoming, Utah, North Dakota and Idaho.

The researchers aren?t clear what the association is between stress and enjoyment but many of the states with the highest stress levels were also states where people seemed to be having the least fun. And rankings have remained fairly consistent, with stress levels in all states remaining statistically unchanged in 2012 compared with 2011.

For example, Hawaii has ranked as the state with the lowest percentage of residents reporting stress on the prior day all five years the survey has been conducted. West Virginia, Kentucky, and Utah, have each ranked within the top five most stressed states for the past five years. West Virginia ranked as the most stressed state in 2012, Kentucky was the top state for stress in 2008 and 2011, and Utah was the top state for stress in 2009 and 2010.

Residents in other high-stress states, Kentucky and West Virginia, were also among the least likely to experience enjoyment. Both of these states have appeared among the bottom five states for experiencing enjoyment at least three times since Gallup began reporting this measure, including last year?s poll.

Regionally, states with stress levels at or above 42 percent were clustered in the Northeast and Midwest, but also included Utah, Oregon, and Washington. Utah is unique in that it routinely ranks among both the highest stress and highest enjoyment states. The researchers said they believed this underscores the complex relationship between stress and other emotions.

On average, 40.6 percent of Americans reported feeling stressed ?yesterday? in this year?s survey and almost 85 percent reported feeling enjoyment ?yesterday.? To see where your state ranked, click here.

SHOWS: Good Morning America

Source: http://abcnews.go.com/blogs/health/2013/04/24/the-mellowest-state-has-obama-connection/

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Dutch diplomat sentenced to 12 years for spying

AMSTERDAM (AP) ? A Dutch court has sentenced a diplomat to 12 years for delivering confidential NATO and the European Union documents to Russian agents.

In Tuesday's ruling, judges at The Hague District Court said Raymond Poeteray had endangered the interests of the Dutch state and its allies by passing on military and political documents over a period of years. He was paid at least ?72,000 ($94,000) between January 2009 and August 2011, the court said.

Poeteray, who worked at the Netherlands' Foreign Affairs Ministry, was arrested in March 2012 in connection with an ongoing case in Germany.

In Germany, a couple that called themselves Andreas and Heidrun Anschlag ? true identies unknown ? are on trial for allegedly compiling the information that Poeteray gathered and sending it to Russia's intelligence agency.

Source: http://news.yahoo.com/dutch-diplomat-sentenced-12-years-spying-091159907.html

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More rain expected for already swollen rivers

AmeriCorps member Cody Turner directs a hose pumping floodwater back into the Mississippi River Monday, April 22, 2013, in Clarksville, Mo. The swollen river has strained a hastily erected makeshift floodwall in Clarksville, creating trouble spots that volunteers were scrambling to patch. (AP Photo/Jeff Roberson)

AmeriCorps member Cody Turner directs a hose pumping floodwater back into the Mississippi River Monday, April 22, 2013, in Clarksville, Mo. The swollen river has strained a hastily erected makeshift floodwall in Clarksville, creating trouble spots that volunteers were scrambling to patch. (AP Photo/Jeff Roberson)

A pickup truck from the Grafton Marina takes two men across a flooded section of marina entrance road, Monday April 22, 2013, in Grafton, Ill. Floodwaters from the Mississippi River have closed the main entrance forcing residents to use a back road away from the river. (AP Photo/The Telegraph, John Badman)

Jeremiah Poitra, right, and Chase Nygaard work to fill TrapBags on Monday April 22, 2013, along fifth street south as part of the city's flood preparation efforts in Fargo, N.D. (AP Photo/The Forum, Michael Vosburg)

Richard Conttrell sits on the front porch of his riverfront home and looks out at the flooded Mississippi River Monday, April 22, 2013, in Clarksville, Mo. The swollen Mississippi River has strained a hastily erected makeshift floodwall in Clarksville, creating two trouble spots that volunteers were scrambling to patch. (AP Photo/Jeff Roberson)

Volunteers work to fill sandbags Monday, April 22, 2013, in Clarksville, Mo. The swollen Mississippi River has strained a hastily erected makeshift floodwall in Clarksville, creating trouble spots that volunteers were scrambling to patch. (AP Photo/Jeff Roberson)

(AP) ? Communities along the Mississippi River and other Midwestern waterways are vigilantly eyeing ? and in some cases hastily fortifying ? makeshift levees to hold back floodwaters that meteorologists say could worsen or be prolonged by looming storms.

An inch of rain was expected to fall from Oklahoma to Michigan through Tuesday, a new drenching that led the National Weather Service to heighten the forecast crest of some stretches of rivers while blunting the progress of other waterways' slow retreat.

Mark Fuchs, a National Weather Service hydrologist, said the latest dousing could be especially troubling for communities along the Illinois River, which he said is headed for record crests.

"Along the Illinois, any increase is going to be cause for alarm, adding to their uncertainty and, in some cases, misery," he said late Monday afternoon.

Last week's downpours brought on sudden flooding throughout the Midwest, and high water is blamed for at least three deaths. Authorities in LaSalle, Ill., spent Monday searching for a woman whose van was spotted days earlier near a bridge, and a 12-year-old boy was in critical condition after being pulled from a river near Leadwood, Mo., about 65 miles south of St. Louis.

The additional rain isn't welcome news in Clarksville, Mo., about 70 miles north of St. Louis.

Days after bused-in prison inmates worked shoulder to shoulder with the National Guard and local volunteers to build a makeshift floodwall of sand and gravel, the barrier showed signs of strain Monday. Crews scrambled to patch trouble spots and build a second sandbag wall to catch any water weaseling through.

In Grafton, Ill., some 40 miles northeast of St. Louis, Mayor Tom Thompson said small community was holding its own against the Mississippi that by early Monday afternoon was 10 feet above flood stage. Waters lapped against some downtown buildings, forcing shops such as Hawg Pit BBQ to clear out and detours to be put up around town ? one key intersection was under 8 inches of water.

"If it gets another foot (higher), it's going to become another issue," Thompson said. Many businesses "are kinda watching and holding their breath. ... Some things are going to really be close to the wire."

Elsewhere, smaller rivers caused big problems. In Grand Rapids, Mich., the Grand River hit a record 21.85 feet, driving hundreds of people from their homes and flooding parts of downtown.

Spots south of St. Louis aren't expected to crest until late this week, and significant flooding is possible in places like Ste. Genevieve, Mo., Cape Girardeau, Mo., and Cairo, Ill. Further downriver, flood warnings have been issued for Kentucky and Tennessee.

___

Salter reported from St. Louis.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-04-23-Spring%20Flooding/id-517a8a3d0f844874923899940e5e6737

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Monday, April 22, 2013

Rizon Jet awarded 'Best Fixed Base Operator' and 'Best Charter ...

"The team at Rizon Jet has continued to forge higher standards, offering wholly better services and standing head and shoulders above the competition for this category," said the magazine's Feature Editor, William Owen. "The company's dedication to fantastic customer service and expansion is certainly the benchmark for others within the industry."

The Business Destinations Travel Awards are designed to showcase those companies whose products and services represent the pinnacle of the business travel industry. Unique in travel accolade platforms, the Business Destinations Travel Awards are chosen not by a select, elite panel of judges but rather by a vast and diverse cross section of primary users and purchasers of corporate travel that make up the magazine's readership.

Captain Hassan Al-Mousawi, Rizon Jet's CEO states; "Being passionate about all areas of our business and investing in our people will always remain one of our first priorities. It's not just the facility, but the people that make the difference. Our business in the Middle East and Europe continues to grow while new opportunities keep presenting themselves. Those recognitions are very stimulating and we are committed to maintain the momentum we have gained in terms of providing the highest service levels and we are pleased to set a new benchmark for our competitors."

Business Destinations is distributed to corporate travel executives and company travel buyers from Fortune 500 companies, MICE solution providers, members of the Association of Corporate Travel Executives (ACTE), as well as other influential members of the business travel community. The magazine's editorial board believes strongly that this exceptional recognition should be determined by the widest possible audience, whose first-hand experience of frequent travel is best suited to select the overall winners.

"The ratings come from important sections of our industry and add enormous weight to our credibility, which is something we treasure"; Hassan Al-Mousawi elaborates, "They are fantastic endorsements and a clear indication that we are getting things right when it comes to providing innovative and outstanding turnkey business aviation services."

Source: http://www.ameinfo.com/rizon-jet-awarded-fixed-base-operator-338490

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Boston Bombings Create Three New Stress Points for Obama

President Obama seemed like a man ready to exhale after the surviving Boston Marathon bomber suspect was captured, but he shouldn?t breathe too easy. Going forward, the tragic episode and its timing have created at least three new areas of stress for his already beleaguered administration.

Immigration setback? The public rollout of comprehensive, bipartisan immigration reform legislation the same week as the marathon bombings was timing at its most unfortunate. The misfortune was compounded by later news that the two suspects in the bombings, which killed three and injured more than 170, were Muslim brothers of Chechen heritage from an area of Russia near Chechnya.

It?s beyond obvious that there are millions of undocumented immigrants in this country who are working at jobs, maybe creating jobs, who are paying taxes or are prospective taxpayers making contributions to their adopted country. But immigration is an emotional issue, and reform opponents now have a perfect hook in the case of the Tsarnaev brothers --?Tamerlan, 26, a legal U.S. resident killed in a shootout with police, and Dzhokhar, 19, a naturalized U.S. citizen taken into custody in serious condition after an intensive day-long manhunt.

The reform package laboriously crafted by the Senate?s bipartisan Group of 8 (and blessed this week by Obama) would grant provisional legal status to most of the 11 million people in the United States without legal documents. Some of them would have a potential path to citizenship years down the road after many border enforcement conditions have been met.

Sen. Jeff Flake, R-Ariz., made what he called ?a conservative case? for the package Saturday in National Review, focused heavily on its border control provisions. Sen. Marco Rubio, R-Fla., ?the Florida senator and much-mentioned Republican presidential possibility, has been issuing a series of ?Myth vs. Fact? releases to counter misinformation. Speaking Saturday to the Nevada GOP, Rubio said the bombings might make passage tougher, but he noted that the brothers got into this country under the broken system he is trying to fix.

Still, reform advocates are up against rising GOP opposition fueled by the bombings. A sampling: After Suspect No. 1 -- Tamerlan -- was killed, conservative Ann Coulter tweeted: ?It?s too bad Suspect #1 won?t be able to be legalized by Marco Rubio, now.? Bryan Fischer, director of issue analysis for the conservative American Family Association, tweeted Saturday that Dzhokhar Tsarnaev is a citizen ?because of our insanely misguided immigration policy.? He wondered why Muslims are being allowed in at all.

In contrast, Obama has spent the week tacitly reminding the country of the Latin motto on the seal of the United States: E Pluribus Unum. Out of many, one.

The American spirit, he said Friday night after Dzhokhar Tsarnaev was captured, ?includes staying true to the unity and diversity that makes us strong -- like no other nation in the world.? Part of the greatness of America and Boston., he added, is that ??we welcome people from all around the world -- people of every faith, every ethnicity, from every corner of the globe. ?So as we continue to learn more about why and how this tragedy happened, let's make sure that we sustain that spirit.?

Obama also celebrated immigration at the prayer service for bombing victims on Thursday. ?Boston opens its heart to the world,? he said. ?Over successive generations, you?ve welcomed again and again new arrivals to our shores -- immigrants who constantly reinvigorated this city and this commonwealth and our nation.?

Some reform proponents are already making a more explicit and practical counter-argument to counter those who view the Boston bombings as a rationale to kill the reform package. They say the current dysfunctional immigration system is a recipe for more terrorism -- not less. ?Immigration reform will strengthen our nation?s security by helping us identify exactly who has entered our country and who has left,? Republican Sens. John McCain and Lindsey Graham said Friday.

That case, always a hard political sell, has become even more difficult over the past week.

FBI Goof? The FBI says ?a foreign government? asked in early 2011 for information about Tamerlan Tsarnaev, the second suspected bomber, who was killed in a shootout with police this week at age 26. The request was ?based on information that he was a follower of radical Islam and a strong believer, and that he had changed drastically since 2010 as he prepared to leave the United States for travel to the country?s region to join unspecified underground groups,? the FBI said.

The changes in Tamerlan were obvious. His aunt said that several years ago he became very religious and started praying five times a day. He grew a long beard. He also married a young American woman, Katherine Russell, and had a daughter with her. Russell ? the daughter of a doctor and nurse from North Kingston, R.I. -- converted to Islam and wore Islamic dress.

When the request for information came in 2011, the FBI said it checked into ?derogatory telephone communications, possible use of online sites associated with the promotion of radical activity, associations with other persons of interest, travel history and plans, and education history? and ?did not find any terrorism activity, domestic or foreign.? But clearly there was no follow-up, or the FBI would probably have noticed that Tamerlan Tsarnaev posted Islamic extremist videos on a YouTube account created in 2012, and flew from New York to Russia in January 2012 and stayed there until July.

Criminal or Combatant? In the latest flare-up of a longrunning conflict between the administration and conservatives, there is already pressure from the right to treat Dzhokhar Tsarnaev as a potential enemy combatant who is not entitled to legal protections (such as the right to remain silent) ? rather than as a potential criminal who is.

?We remain under threat from radical Islam and we hope the Obama Administration will seriously consider the enemy combatant option,? ?Graham wrote on Facebook right after Tsarnaev was taken into custody. He said the accused perpetrators of last Monday?s two bombings were ?not common criminals? but terrorists, and ?the least of our worries is a criminal trial which will likely be held years from now.?

?

Source: http://news.yahoo.com/boston-bombings-create-three-stress-points-obama-130335364--politics.html

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Strong quake hits China; 156 dead, more than 5,500 injured

By Ben Blanchard

BEIJING (Reuters) - A strong 6.6 magnitude earthquake hit a remote, mostly rural and mountainous area of southwestern China's Sichuan province on Saturday, killing at least 156 people and injuring about 5,500 close to where a big quake killed almost 70,000 people in 2008.

The earthquake, China's worst in three years, occurred at 8.02 a.m. (0002 GMT) in Lushan county near Ya'an city and the epicenter had a depth of 12 km (7.5 miles), the U.S. Geological Survey said.

The quake was felt by residents in neighboring provinces and in the provincial capital of Chengdu, causing many people to rush out of buildings, according to accounts on China's Twitter-like Sina Weibo microblogging service.

State media said 156 people had been confirmed dead with more than 5,500 injured.

President Xi Jinping and Premier Li Keqiang said all efforts must be put into rescuing victims to limit the death toll.

After arriving at the disaster zone by helicopter, Li directed earthquake relief efforts from a plaza in Longmen township in Lushan, Xinhua said.

Li asked that a road be opened to Baoxing county, one of the most affected by the earthquake, and that rescuers "act quickly" in their efforts, Xinhua quoted Li as saying.

"The current most urgent issue is grasping the first 24 hours since the quake's occurrence, the golden time for saving lives," Xinhua news agency quoted Li as saying earlier.

Xinhua said 6,000 troops were heading to the area to help with rescue efforts. State television CCTV said only emergency vehicles were being allowed into Ya'an, though Chengdu airport had reopened.

Most of the deaths were concentrated in Lushan, where water and electricity were cut off. Pictures on Chinese news sites showed toppled buildings and people in bloodied bandages being treated in tents outside the hospital, which appeared only lightly damaged.

Rescuers in Lushan had pulled 32 survivors out of rubble, Xinhua said. In villages closest to the epicenter, almost all low rise houses and buildings had collapsed, according to footage broadcast on state television.

This aerial photo released by China's Xinhua news agency shows destroyed houses after a powerful earthquake hit Taiping town of Lushan County in Ya'an City, southwest China's Sichuan Province, ... more? This aerial photo released by China's Xinhua news agency shows destroyed houses after a powerful earthquake hit Taiping town of Lushan County in Ya'an City, southwest China's Sichuan Province, Saturday, April 20, 2013. The powerful earthquake jolted Sichuan province Saturday near where a devastating quake struck five years ago. (AP Photo/Xinhua, Liu Yinghua) NO SALES less? ?

"We are very busy right now, there are about eight or nine injured people, the doctors are handling the cases," said a doctor at a Ya'an hospital who gave her family name as Liu.

The hospital was seeing head and leg injuries, she added.

"SHAKES AND TREMORS"

The China Meteorological Association warned of a possibility of landslides occurring in Lushan county on Saturday and Sunday, the agency said in a statement on its website.

A resident in Chengdu, 140 km (85 miles) from Ya'an city, told Xinhua he was on the 13th floor of a building when he felt the quake. The building shook for about 20 seconds and he saw tiles fall from nearby buildings.

Ya'an is a city of 1.5 million people and is considered one of the birthplaces of Chinese tea culture. It is also the home to one of China's main centers for protecting the giant panda.

"There are still shakes and tremors and our area is safe. The pandas are safe," said a spokesman with Ya'an's Bifengxia nature park, a tourism park that houses more than 100 pandas.

Shouts and screams were heard in the background while Reuters was on the telephone with the spokesman.

"There was just an aftershock, an aftershock, our office is safe," he said.

Numerous aftershocks jolted the area, the largest of which was magnitude 5.1.

Sichuan is one of the four major natural-gas-producing provinces in China, and its output accounts for about 14 percent of the nation's total.

Sinopec Group, Asia's largest oil refiner, said its huge Puguang gas field was unaffected.

The U.S. Geological Survey initially put the magnitude at 7, but later revised it down.

The devastating May 2008 quake was 7.9 magnitude.

(Additional reporting by Melanie Lee and Lu Jianxin in SHANGHAI and Sui-Lee Wee in BEIJING; Editing by Jonathan Standing and Sanjeev Miglani)

Source: http://news.yahoo.com/magnitude-6-9-quake-strikes-sichuan-region-china-002702079.html

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Sunday, April 21, 2013

Structure of cell signaling molecule suggests general on-off switch

Structure of cell signaling molecule suggests general on-off switch [ Back to EurekAlert! ] Public release date: 21-Apr-2013
[ | E-mail | Share Share ]

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center

DURHAM, N.C. A three-dimensional image of one of the proteins that serves as an on-off switch as it binds to receptors on the surface of a cell suggests there may be a sort of main power switch that could be tripped. These surface receptors are responsible for helping cells discern light, set the heart racing, or detect pain.

The finding, published online April 21, 2013, in the journal Nature by a research collaboration involving this year's Nobel laureates in chemistry, could help in the development of more effective drugs to switch on or off the cell receptors that regulate nearly every bodily function. Already, up to half of all drugs engage these receptors, including antihistamines and beta blockers, but many of the intricacies of how these important proteins work remain unknown.

"It's important to understand how this extraordinary family of receptors work," said co-author Robert J. Lefkowitz, M.D., James B. Duke Professor of Medicine and Howard Hughes Medical Institute Investigator. "This is the kind of finding that answers a basic curiosity, but can also be of benefit if we can develop new drugs or improve the ones we have."

The research marks a collaborative reunion between Lefkowitz and Brian K. Kobilka, M.D., chair of molecular and cellular physiology at Stanford University School of Medicine. The two researchers friends who first collaborated when Kobilka was a trainee in Lefkowitz's laboratory at Duke - shared the 2012 Nobel Prize in Chemistry for their discoveries involving the G-protein coupled receptors (GPCRs), which are activated by signaling proteins to detect hormones, neurotransmitters, pain, light.

In the current work, the researchers used X-ray crystallography to develop an atom-scale image of one of the principal signaling molecules that regulate GPCRs. This protein is called beta-arrestin1, which, among other things, works to dim a cell's response to hormones such as adrenalin.

The researchers were able to isolate and capture the beta-arrestin1 protein in an active state as it binds to a segment of the GPCR a first. That snapshot, in high resolution, revealed that the structural conformation or shape of the protein in its active state is strikingly different than when it is inactive.

Such changes suggest there may be a general molecular mechanism that activates the beta-arrestin1 a sort of main switch that controls the multi-functional signaling proteins.

"It's like there are brakes on in beta-arrestin1, and then when the beta-arrestin1 binds to a GPCR, the brakes are released, thereby activating beta-arrestin1," said Arun K. Shukla, PhD, assistant professor of medicine at Duke and co-lead author of the study.

The researchers are now pursuing additional structural imaging of the signaling complex consisting of beta-arrestin1 and the entire receptor protein.

###

In addition to Lefkowitz and Shukla, study authors at Duke include Kunhong Xiao, Rosana I. Reis, Wei-Chou Tseng, Dean P. Staus, Li-Yin Huang and Prachi Tripathi-Shukla.

Authors from Stanford include Aashish Manglik, Andrew C. Kruse, Daniel Hilger, William I. Weis and Kobilka. Authors from the University of Chicago include Serdar Uysal, Marcin Paduch, Akiko Koide, Shohei Koide and Anthony A. Kossiakoff.

The study was funded by the Stanford Medical Scientist Training Program, the American Heart Association, the National Science Foundation, the Mathers Foundation and the National Institutes of Health (NS028471, HL16037, HL70631, GM072688, GM087519, HL 075443).


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Structure of cell signaling molecule suggests general on-off switch [ Back to EurekAlert! ] Public release date: 21-Apr-2013
[ | E-mail | Share Share ]

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center

DURHAM, N.C. A three-dimensional image of one of the proteins that serves as an on-off switch as it binds to receptors on the surface of a cell suggests there may be a sort of main power switch that could be tripped. These surface receptors are responsible for helping cells discern light, set the heart racing, or detect pain.

The finding, published online April 21, 2013, in the journal Nature by a research collaboration involving this year's Nobel laureates in chemistry, could help in the development of more effective drugs to switch on or off the cell receptors that regulate nearly every bodily function. Already, up to half of all drugs engage these receptors, including antihistamines and beta blockers, but many of the intricacies of how these important proteins work remain unknown.

"It's important to understand how this extraordinary family of receptors work," said co-author Robert J. Lefkowitz, M.D., James B. Duke Professor of Medicine and Howard Hughes Medical Institute Investigator. "This is the kind of finding that answers a basic curiosity, but can also be of benefit if we can develop new drugs or improve the ones we have."

The research marks a collaborative reunion between Lefkowitz and Brian K. Kobilka, M.D., chair of molecular and cellular physiology at Stanford University School of Medicine. The two researchers friends who first collaborated when Kobilka was a trainee in Lefkowitz's laboratory at Duke - shared the 2012 Nobel Prize in Chemistry for their discoveries involving the G-protein coupled receptors (GPCRs), which are activated by signaling proteins to detect hormones, neurotransmitters, pain, light.

In the current work, the researchers used X-ray crystallography to develop an atom-scale image of one of the principal signaling molecules that regulate GPCRs. This protein is called beta-arrestin1, which, among other things, works to dim a cell's response to hormones such as adrenalin.

The researchers were able to isolate and capture the beta-arrestin1 protein in an active state as it binds to a segment of the GPCR a first. That snapshot, in high resolution, revealed that the structural conformation or shape of the protein in its active state is strikingly different than when it is inactive.

Such changes suggest there may be a general molecular mechanism that activates the beta-arrestin1 a sort of main switch that controls the multi-functional signaling proteins.

"It's like there are brakes on in beta-arrestin1, and then when the beta-arrestin1 binds to a GPCR, the brakes are released, thereby activating beta-arrestin1," said Arun K. Shukla, PhD, assistant professor of medicine at Duke and co-lead author of the study.

The researchers are now pursuing additional structural imaging of the signaling complex consisting of beta-arrestin1 and the entire receptor protein.

###

In addition to Lefkowitz and Shukla, study authors at Duke include Kunhong Xiao, Rosana I. Reis, Wei-Chou Tseng, Dean P. Staus, Li-Yin Huang and Prachi Tripathi-Shukla.

Authors from Stanford include Aashish Manglik, Andrew C. Kruse, Daniel Hilger, William I. Weis and Kobilka. Authors from the University of Chicago include Serdar Uysal, Marcin Paduch, Akiko Koide, Shohei Koide and Anthony A. Kossiakoff.

The study was funded by the Stanford Medical Scientist Training Program, the American Heart Association, the National Science Foundation, the Mathers Foundation and the National Institutes of Health (NS028471, HL16037, HL70631, GM072688, GM087519, HL 075443).


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/dumc-soc041813.php

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Strong Winds Postpone New US Rocket's Launch Debut

The launch debut of a new privately built rocket will have to wait at least one more day after strong winds thwarted an attempted liftoff on Saturday (April 20).

The unmanned Antares rocket was poised to launch into orbit Saturday afternoon from a new seaside pad at NASA's Wallops Flight Facility along Virginia's Eastern Shore when the foul weather intervened. The rocket's next chance to launch occurs Sunday (April 21) at 5 p.m. EDT (2100 GMT).

Orbital Sciences had hoped to launch Antares at 5 p.m. EDT on Saturday, but unacceptably strong winds in the upper atmosphere ? which could pose a risk to the rocket in mid-flight ? prompted them to delay liftoff by an hour at first, then call off the attempt altogether. [LaunchPad Photos: 1st Antares Rocket Ready to Fly]

It is the second delay in three days for Antares' debut launch. A minor equipment glitch led Orbital officials to call off a launch try on Wednesday (April 17) when a data cable at the pad separated from the rocket earlier than planned.

Built by the Dulles, Va.-based spaceflight firm Orbital Sciences Corp., the Antares rocket is a 13-story booster designed to launch the company's unmanned Cygnus spacecraft on cargo delivery missions to the International Space Station. Orbital has a $1.9 billion contract to provide at least eight cargo delivery flights to the station using Cygnus and Antares.?

For this first flight, the Antares rocket will not be carrying an active Cygnus spacecraft into orbit. Instead, the rocket is topped with a cylindrical "mass simulator" that mimics the shape and weight of an actual Cygnus vehicle, officials said. The mockup is also equipped with 70 sensors to measure the effects of launch on an Antares vehicle.

Orbital has also added three tiny NASA satellites ? coffee-cup-size Phonesats ? and a small commercial cubesat called Dove-1 to the mass simulator for this test flight. The miniature satellites will be deployed in orbit after launch, Orbital officials said.

NASA's Phonesats are experiments designed to test how well commercial smartphones can be used as the main computers on cheap satellites.

Orbital Sciences is one of two American spaceflight companies with NASA contracts for? commercial resupply missions to the International Space Station. The other firm is Space Exploration Technologies (SpaceX) of Hawthorne, Calif., which has a $1.6 billion contract to fly at least 12 cargo delivery missions to the space station using its Falcon 9 rockets and robotic Dragon space capsules.

SpaceX launched its first test flight to the station in May 2012 and has flown two official cargo deliveries since then. NASA retired its space shuttle fleet in 2011 and is relying on private spacecraft to keep the space station stocked with supplies. The space agency also plans to begin flying American astronauts to the station on commercial spacecraft by 2017.

Email Tariq Malik at tmalik@space.com or follow him @tariqjmalikand Google+. Follow us @Spacedotcom, Facebookand Google+. Original article on?SPACE.com.

Copyright 2013 SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/strong-winds-postpone-us-rockets-launch-debut-205323747.html

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Jobless rates plummet in states with housing recovery

By Lisa Lambert

(Reuters) - Unemployment rates dropped in most states in March from the year before, including California where joblessness fell to a four-year low, as the recovery picked up in places hit hard by the housing downturn.

Federal data released on Friday showed that, altogether, unemployment rates fell from March 2012 in 39 states and the District of Columbia, increased in eight, and were the same in three. From February, rates dropped in 26 states and the District of Columbia, rose in seven and were unchanged in 17.

Nevada had the sharpest decrease over the year - the rate fell to 9.7 percent from 11.6 percent in March 2012.

In California the unemployment rate fell to 9.4 percent, the lowest since December 2008 and more than a percentage point below March 2012, when it was 10.7 percent.

The state's economic recovery is now taking hold in areas where the housing bust wrought the most damage, according to Stephen Levy director of the Center for Continuing Study of the California Economy, a private research organization in Palo Alto.

"The good news is that the recovery is spreading beyond the Bay Area. There are parts of southern California, such as Los Angeles County, that were badly hit by the housing crash, that are showing signs of recovery," he said.

California, he added, "is emerging again as an economic growth leader led by traditional strengths in technology, trade, tourism, agriculture and the application of creativity to the design of goods and services in demand worldwide".

California and Nevada, two places where housing had once flourished, have consistently had some of the highest unemployment rates in the country over the last few years. Even with the drops in March, Nevada held the highest unemployment rate of all the states and California the third highest.

Nevada's rate also rose from 9.6 percent in February and the state lost 2,900 jobs during the month, when seasonally adjusted.

"So far this year, job growth appears to be slowing a bit after exceeding expectations in the second half of 2012," said Bill Anderson, chief economist for Nevada's employment department, in a statement.

"Despite the decline in non-farm payroll jobs and a slight increase in the unemployment rate, nearly all over-the-year comparisons are evidence of an ongoing mild recovery in Nevada's labor market," he added.

Rhode Island had the second biggest decline from the year before, with its jobless rate dropping to 9.1 percent from 10.6 percent in March 2012, followed by Florida, where the rate was 8.9 percent compared to 7.5 percent the year before.

In Idaho, Washington, Hawaii and Colorado, the jobless rates also were more than a percentage point lower than a year before.

Unlike previous downturns, the 2007-09 recession was fairly uniform, sparing only a few states. The recovery, though, began unevenly, with states rich in oil, natural gas and commodities pulling ahead and those where housing had been the major source of jobs limping for years after the real estate market collapsed.

Meanwhile, in March the Illinois jobless rate rose the most since March 2012, to 9.5 percent from 8.8 percent.

The state also had the second highest jobless rate in the country last month, followed by California and Mississippi, even as it added 36,000 jobs from the year before, according to its employment department.

"Economic uncertainty nationally and abroad dampened our country's job growth. When that happens, Illinois' share tends to be a negative number," said Jay Rowell, director of the employment department, in a statement.

"Monthly snapshots capture a moment in time. When those moments are evaluated together, we see progress away from a global recession and through a stubborn economic growth cycle," he added.

Indiana, Mississippi, New Hampshire, Pennsylvania, Delaware, North Dakota and Wisconsin also saw rate increases from March 2012. Meanwhile, the rates were unchanged in Alabama, New Mexico, and West Virginia.

NEW JERSEY'S UNEMPLOYMENT RATE TUMBLES

From February, the jobless rate increases were mild, with Louisiana seeing the biggest rise, to 6.2 percent from 6 percent.

Alaska, Florida, New Jersey, Rhode Island, Utah, Vermont, and Virginia experienced the largest decreases of 0.3 percentage points each.

New Jersey's unemployment rate drop in March to 9 percent was greeted as good news by the state's political leaders.

Last year, the jobless rate climbed steadily to the highest level in 35 years, 9.8 percent in July. Along with neighboring New York, New Jersey was the only state where the average jobless rate increased in 2012 from 2011. The signs of a slow recovery prompted New Jersey Governor Chris Christie to abandon claims that the state was in the middle of a comeback.

But now the rate has edged down and the state added 10,400 private sector jobs in March.

"Once again, jobs and unemployment are moving in the right directions, reflecting the growing strength in the state's economy," New Jersey's Chief Economist Charles Steindel said in a statement.

(Reporting by Lisa Lambert, additional reporting by Hilary Russ in Rutgers, New Jersey and by Tim Reid in Los Angeles; editing by Sofina Mirza-Reid and Chizu Nomiyama)

Source: http://news.yahoo.com/jobless-rates-plummet-states-housing-recovery-175318304--finance.html

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